Anti-Glaucoma


Dorzamed (Eye Drops)
(Dorzolamide)

COMPOSITION
Each ml contains dorzolamide (in the form of hydrochloride) 20 mg.

INDICATIONS
- Increased intraocular pressure;
- Open-angle glaucoma (including pseudoexfoliative glaucoma and other types of secondary open-angle glaucoma).

CONTRAINDICATIONS
- Hypersensitivity to drug components;
- Severe renal insufficiency (CC less than 30 ml/min);
- Hyperchloremic acidosis;
- Pregnancy and lactation period;
- Child age.

ADVERSE EFFECTS

Topical reactions: burning, pricking, itching in eyes, visual blurring, eyelid irritation, conjunctivitis, blepharitis; seldom iridocyclitis.
Systemic reactions: bitter taste in mouth is possible, nausea, headache, paresthesia, asthenia, sinusitis, rhinitis, nephrourolithiasis, hypersensitivity reactions (including appearance of skin rash, angioneurotic edema, bronchospasm).

DOSAGE AND ADMINISTRATION
Only for topical application. Conjunctivally. At monotherapy Dorzamed is administered by 1 drop in each affected eye 3 times per day.
In combination with beta-adrenoblockers for topical administration the preparation is administered by 1 drop in each affected eye 2 times per week. During concomitant application of other topical ophthalmological agents the interval between instillations can be less than 10 minutes. In case of shifting from treatment with other ophtalmological preparation to Dorzamed, the preparation is cancelled after usual daily dosage, and treatment with Dorzamed is started the next day.

DRUG INTERACTIONS

Dorzolamide potentiates the effect of other Anti-glaucoma. Acetazolamide increases the risk of Dorzamed systemic adverse effects development during oral administration. The effect of such acetylcholinesterase inhibitors, as physostigmine, galantamine, neostigmine or pyridostigmine (often used at myasthenia) may be decreased by dorzolamide. At combined application with diuretics significant potassium loss is possible. During concomitant application with phenytoin osteoporosis may worsen.

PRECAUTIONS

Eye drops Dorzamed contain a preservative, therefore persons, wearing contact lenses, should take off them before drug administration and insert them again not earlier then 15 minute after instillation.

MANUFACTURED FORM
5 ml in plastic vial with dropping stopper and screw cap, supplied with guard ring. Vial in carton box with packaging leaflet.


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